MSNBIO 2622 - Spring 2014

Mechanisms and Clinical Presentation of Pain Schedule

(MSNBIO 2622, 3 semester hours)

Mondays and Thursdays, 3:30 - 5:00 p.m., 1495 BSTWR

G.F. Gebhart, Course Director
E-mail: gebhartgf@upmc.edu
Phone: 412-383-5911
Location: W1444 BSTWR

DateTopicPresenterReading Assignments

09 January

Course organization, pain taxonomy, overview

G. Gebhart

- Melzack & Wall (1965) - Pain mechanisms: A new theory

- E. Perl (2006) - Ideas about pain, a historical view

13 January

The Importance of the translational basis for pain treatment

A. Wasan

16 January

Nociceptors (definition, assessment, heterogeneity, characteristics)

G. Gebhart

-Snider & McMahon (1998) - Tackling pain at the source: new ideas about nociceptors

-Djouhri & Lawson (2004) - Ab-fiber nociceptive primary afferent neurons...

20 January

No Class - Martin Luther King Holiday

 

23 January

Pain Fellows case reports:

  • K. Castello

  • H. Dani

  • C. Daves

All

27 January

Pain Fellows case reports:

  • E. Garay

  • S. Ikezi

  • G. Jain

All

30 January

Pain Fellows case reports:

  • A. Madupu

  • N. Sawiris

  • P. Singh

All

 

3 February

Injury-induced changes in afferent signaling

M. Gold

- Hucho & Levine (2007) - Signaling pathways in sensitization
- Gold & Gebhart (2010) - Nociceptor sensitization in pain pathogenesis
-
Cregg et al. (2010) Pain channelopathies

6 February

Dorsal horn - structure and function

R. Koerber

- Todd (2010) - Neuronal circuitry for painprocessing in the dorsal horn

10 February

Injury-induces changes in dorsal horn signaling

R. Koerber

- Sandkuhler (2009) - Models and mechanisms of hyperalgesia

13 February

Ascending pathways

D. Molliver

- Craig (2003) - Pain review
- Sharif-Naeini & Basbaum (2011) - Targeting pain

17 February

Descending modulatory pathways

G. Gebhart

- Ossipov et al (2010) Central modulation of pain 

19 February

Manoj Puthenveedu Seminar

All

4:00, Room 1103 Scaife

20 February

Itch and pain

S. Ross

- Ikoma et al (2006) - The neurobiology of itch 

24 February

Growth factors, cytokines chemokines and pain

K. Albers

- Miller et al. (2009) - Cytokine and chemokine regulation of sensory neuron fuction 

27 February

Neuropathic pain (models, mechanisms)

M. Gold

- Costigan et al. (2009) - Neuropathic pain: A maladaptive response of the nervous system to damage

3 March

Supraspinal representation of pain

J. Ibinson

- Schweinhardt & Bushnell (2010) - Pain imaging in health and disease 

6 March

Cancer pain (models and mechanisms)

B. Davis

-Bapat et al (2011)Perineural invasion and associated pain in pancreatic cancer
-Raphael et al (2010) Cancer pain

 

Distribution of Progress Exam, due back 4 March

  

10, 14 March

No Class - Spring Break

  

17 March

Preclinical approaches to study the genetics of pain and analgesia

W. Lariviere

-Mogil (2012) -Pain genetics: past, present & future
-Lacroix et al. (2009) - Progress in genetic studies...

19 March

Raj Raja Seminar

 All

 4:00, Room 1103 Scaife

20 March

Genetic factors of human pain and their clinical relevance

I. Belfer

-Max & Stewart (2008) Molecular epidemiology...

-Young et al. (2012) Genetic basis of pain variability: recent advances

-Belfer & Dai (2010) Phenotyping & genotyping neuropathic pain

24 March

Psychosocial assessment and behavioral treatment of chronic pain

C. Greco, Psychiatry

 

27 March

Visceral pain (clinical presentation, mechanisms)

K. Bielefeldt, Medicine/GI

-Gebhart & Bielefeldt (2008) – Visceral pain

31 March

Chronic low back pain 

  

 3 April

Pain and sleep

 J. Karp, Psychiatry

 
 

Class paper due

  

 7 April

Pain in the aged

  

10 April

Headache

  

14 April

?

  

16 April

Claudia Campbell Seminar

 All

4:00, Room 1103 Scaife

17 April

Student presentations

  

21 April

Student presentations

  

Schedule for Spring 2008
Schedule for Spring 2009
Schedule for Spring 2011
Schedule for Spring 2012
Schedule for Spring 2013