Pain Course (MSNBIO 2622) - Spring 2011

Mechanisms and Clinical Presentation of Pain Schedule through February

(MSNBIO 2622, 3 semester hours)

Mondays and Thursdays, 3:30 - 5:00 p.m., 1495 BSTWR

G.F. Gebhart, Course Director
Phone: 412-383-5911
Location: W1444 BSTWR


Date Topic Presenter Reading Assignments
10 January Course organization, pain terminology, pain mechanisms overview G. Gebhart Melzack and Wall (1965) -Pain Mechanisms: A new Theory
E. Perl (2006) - Ideas about pain, a historical view
13 January Nociceptors (definition, assessment, characteristics, heterogeneity) B. Davis Snider & McMahon (1998) - Tackling pain at the source: new ideas about nociceptors.Djouhri & -Lawson (2004) - Ab-fiber nociceptive primary afferent neurons
17 January No Class - Martin Luther King Holiday    
20 January Nociceptors(content, receptor/channel expression,transduction pathways) B. Davis click here to download presentation in pdf format
24 January Injury-induced changes in afferent signaling M. Gold Hucho & Levine (2007) - Signaling pathways in sensitizationGold & Gebhart (2010) - Nociceptor sensitization in pain pathogenesisCregg et al. (2010) Pain channelopathies click here to download presentation in pdf format
27 January Dorsal horn - structure and function R. Koerber Todd (2010) - Neuronal circuitry for painprocessing in the dorsal horn
31 January Injury-induces changes in dorsal horn signaling R. Koerber Sandkuhler (2009) - Models and Mechanisms of Hyperalgesia and Alodyniaclick here to download presentation in pdf format
3 February Growth Factors, Cytokines and Pain K. Albers Miller et al. (2009) Austin,Moalem-Taylor(2010) Cytokine and Chemokine Regulation of Sensory Neuron Functionclick here to download presentation in pdf format
7 February Ascending pathways D. Molliver Craig (2003) - Pain Mechanisms: Labeled Lines Versus Convergence in Central Processing
10 February Descending modulatory pathways G. Gebhart Ossipov et al (2010) –Central modulation of pain
14 February Supraspinal representation of pain J. Ibinson Schweinhardt & Bushnell (2010) -Pain imaging in health and disease
17 February Cheryl StuckySeminar
Distribution of 1st Exam, due back 21 Feb
All 4:00, room 1495 BST
21 February Neuropathic pain (models, mechanisms) W. Lariviere Costigan et al. (2009) - Neuropathic pain: A maladaptive response of the nervous system to damage
24 February Pain and depression J. Karp Moskowitz & Fishman (2006) – The Neurobiological and therapeutic.Karp et al. (2008) - Advances in understanding the mechanisms and management of persistent pain in older adults.
28 February Cynthia Hingtgen Seminar All 4:00, room 1495 BST
3 March Complementary and Alternative Medicine approaches to pain management R. Glick, Center, Integrative Medicine Berman (2010) - Acupuncture for chronic low back pain
7, 10 March No Class - Spring Break    
14 March Visceral Pain (clinical presentation, mechanisms) K. Bielefeldt, Medicine/GI Gebhart & Bielefeldt (2008) - Visceral pain
16 March Jay Pasricha Seminar All 4:00, room 1105A Scaife
17 March Sex and Pain M. Gold Fillingim (2010), J Pain review Greenspan (2007), J Pain review
21 March Pain Genetics (basics, non-human animal) W. Lariviere Foulkes & Wood (2008) - Pain GenesLariviere & Mogil (2010), Methods Mol Biol
24 March Headache R. Kaniecki, Director, The Headache Center  
28 March Musculoskeletal Pain A. Delitto, Physical Therapy  
31 March Opioid and NSAID Analgesics G. Gebhart no paper
4 April Cancer Pain B. Davis Mantyh (2006) - cancer reviewShinichi Yachida (2010) -PDAC takes decadesFoulkes and Wood (2008) -Pain Genes
7 April Pain Genetics (human) I. Belfer Diatchenko review (2007) - Genetic architecture of human pain perceptionMax review (2008) - The molecular epidemiology of pain:a new discipline for drug discovery
11 April TBD    
14 April Psychosocial assessment and behavioral treatment of chronic pain C. Greco, Psychiatry  
20 April Mike Salter Seminar All Title and Location to be announced
18 April Student Presentations All  
21 April Student Presentations All  

If you have a disability for which you are or may be requesting an accommodation, you are encouraged to contact both the course director and Disability Resources and Services, 216 William Pitt Union, (412) 648-7890/(412) 383-7355 (TTY), as early as possible in the term.  DRS will verify your disability and determine reasonable accommodations for this course.

            1. Students registered in the course will be asked to select from a list a topic for a paper (10 double spaced pages, not including references, figures or tables).  The paper is Due Thursday noon, 14 April and will constitute - in conjuction with the oral presentation of the topic - about 50% of the course grade.  Students will give an oral presentation (20-30 min) of the paper/topic at the end of the semester.

Schedule for Spring 2008
Schedule for Spring 2009