Elias Aizenman, PhD Professor, Neurobiology
Injurious processes in the brain lead to the activation of signaling cascades that eventually result in the demise of neurons. In Dr. Aizenman's laboratory, cellular pathways leading to cell death are being molecularly dissected in order to provide novel therapeutic targets to treat neurodegenerative disorders. This laboratory works on potential final common mediators of cell death signaling events that can be effectively targeted to treat neuronal disorders. This work is primarily focused on acute neuronal injury, such as stroke, although the results from these studies could have broader applications to more chronic neurodegenerative conditions, such as Parkinson's disease, ALS and Alzheimer's disease. Over the last several years, the laboratory has investigated redox and photic regulation of NMDA receptors, excitotoxicity, dopamine oxidation pathways, zinc-mediated neurotoxicity, and potassium channel facilitated forms of neuronal apoptosis, among other topics.
Recent key publications: